Management Comment Our maximum screening period by protocol is 28 days with an average screening time to date of approximately 19 days. Accordingly, we expect all patients in screening to complete that process sometime in March. This is a 12-month study and accounting for time for database lock and data analysis, we expect to announce results in the second quarter of 2018. The primary endpoint of the PRONTO study is cardiac test response is defined by a change in NT-proBMP.