Additional Relevant Details
Subjects who received multiple doses of 10 mg, 20 mg, 40 mg, or 60 mg of IONIS-ANGPTL3-LRx achieved dose-dependent, statistically significant mean reductions at Day 37 in ANGPTL3 of up to 83 percent (p ≤0.001).  These subjects also experienced statistically significant mean reductions in triglycerides of up to 66 percent (p ≤0.001), in LDL-C of up to 35 percent (p ≤0.001), and in total cholesterol of up to 36 percent (p ≤0.001).  In this study, IONIS-ANGPTL3-LRx displayed a favorable safety and tolerability profile.  There were no discontinuations due to adverse events and no clinically meaningful platelet declines.