Additional Relevant Details  FPL is a rare lipid disorder characterized by abnormal fat distribution across the body and a range of metabolic abnormalities, including severe type 2 diabetes, high triglycerides, and accumulation of fat in the liver. The EC's approval follows a positive opinion in June from the European Medicine Agency's (EMA) Committee for Orphan Medicinal Products. Volanesorsen is being developed for the treatment of two rare, genetic cardiometabolic diseases: familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy.