Additional Relevant Details 10 patients received treatment last week with the Probuphine (buprenorphine) implant, making them the first patients in the United States to receive the medication since it was approved by the U.S. Food and Drug Administration (FDA) on May 26, 2016 for the maintenance treatment of opioid dependence. Probuphine was developed using Titan's long-term, continuous drug delivery platform ProNeura.