Clinical Data
The increase in six minute walk distance (“6MWD”) through 16 weeks of treatment that was previously reported was sustained through 32 weeks of treatment and was not significantly different from that at week 16 in the same set of patients. Bardoxolone methyl-treated patients with connective tissue disease (“CTD”)-associated PAH had similar sustained increases in 6MWD through week 32. Bardoxolone methyl was well-tolerated, and fewer adverse events were reported during the extension study than during the first 16 weeks of treatment.