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Actinium Pharmaceuticals Announces Positive Safety and Efficacy Results From Phase 1 Actimab-A Trial in Patients With Newly Diagnosed Acute Myeloid Leukemia and Provides Guidance on Plans for Phase 2 Clinical Trial

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  • Analysis of clinical trials from Actimab-A portion of Actinium's HuM195-Alpha program show low peripheral blast burden results in improved patient responses
  • Phase 2 trial to begin enrolling patients in 2H:2016 with revised protocol incorporating latest findings

     The median age of patients in the trial was 77 years (range 68-87 years) of which 67% had intermediate-risk cytogenetics and 33% had unfavorable cytogenetics. Importantly, the complete response rate at the dose level which the Company intends to progress into the Phase 2 trial was 50% in patients with low peripheral blast (PB) burden. Most serious adverse events (SAEs) were infections and cytopenias that are considered to be consequences of AML and not drug related.
  • http://ir.actiniumph...
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    Occurred on:
    Jun 01, 2016
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    Related Keywords Acute Myeloid Leukemia, Actimab-a, Hum195-alpha, Cytogenetics