Management Comment “Many newly diagnosed AML patients cannot tolerate intensive chemotherapy, which limits their available treatment options,” said Anthony S. Stein, M.D., study investigator and co-director of the leukemia program at City of Hope Cancer Center. “Based on the safety and efficacy demonstrated in clinical studies of AG-221 and AG-120 in relapsed / refractory AML, there is potential to provide a new treatment option for newly diagnosed IDH mutant AML patients by combining these therapies with VIDAZA® in the frontline setting.”