Catalyst

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Bellicum Pharma (BLCM) to initiate enrollment in Phase 1 trial of BPX-601 in patients with non-resectable pancreatic cancer in mid 2016

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Additional Information

Management Comment "Our GoCAR-T product candidate BPX-601 contains our proprietary iMC or inducible MyD88/CD40 activation switch that is designed to treat solid tumors expressing prostate stem cell antigen or PSCA. Unlike standard CARs, which is depended on antigen for activation and proliferation, GoCAR-T places the co-stimulatory signal on the rimiducid controlled switch which designed to allow control the T cell survival in the absence of antigen signaling and full activation and proliferation in the presence of both antigen and rimiducid.We will be studying BPX-601 in solid tumors over expressing PSCA, an attractive proprietary target in which there is significant unmet medical need. The initial planned indication is non-resectable pancreatic cancer and the initial Phase I clinical trial is also expected to begin enrollment in mid 2016. Preclinical data with BPX-601 presented at ASH 2015 showed strong antitumor activity and enhanced T cell proliferation, persistence and in vivo anti-tumor activity compared to traditional CAR T therapies."-CEO Tom Farrell
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Additional Relevant Details See the Q&A with Biren Amin at the end of this source for additional information
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Catalyst Date
Occurred on:
Aug 08, 2016
Occurred Source:
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Related Keywords Phase 1 Trial, Enrollment, Bpx-601, Pancreatic Cancer, Car-t, Gocar-t, Solid Tumors