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Development of Omecamtiv Mecarbil Questionable to Continue to Phase 3 - Decision Expected This Year

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Additional Relevant Details Cytokinetics and Amgen in partnership will continue to develop Omecamtiv mecarbil  for the treatment of heart failure despite it failing its primary efficacy endpoint in the ATOMIC-AHF Phase 2b study in 2013.  A recent study (COSMIC-HF) in 2015 met its primary pharmacokinetics objective, but did not test for efficacy.  Omecamtiv mecarbil is currently being studied on Japanese patients with heart failure, but the primary endpoint observes dose escalation.  
Additional Relevant Details "the advancement of omecamtiv mecarbil to Phase 3 clinical development with a cardiovascular outcomes clinical trial expected to initiate in the fourth quarter of 2016"
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Catalyst Date
Occurred on:
Sep 01, 2016
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Related Keywords Omecamtiv Mecarbil, Japan, Heart Failure